Prevention & lipidsRandomised controlled trial
Influence of repeated plaque visualization on cardiovascular risk reduction after 3 years: a randomized controlled trial
- Randomised controlled trial
Authors' conclusion
A nurse-led programme, combining personalized patient visualization of CAC imaging with statin therapy, is beneficial for improving CV risk. Recalling the presentation of CAC images through repeated visual exposure may influence risk reduction.
Study context
- Population
- Asymptomatic, statin-naïve participants, 40–70 years, with family history of premature CAD and coronary artery calcium (CAC) score 1–400
- Participants
- 449 participants
- Comparison
- Intervention vs Standard care
- Interventionn = 220
- Primary endpoint
- Change in Framingham Risk Score (FRS)
- Follow-up
- 36 months
Primary result
Change in FRS
Difference in differences
−3.4 %
95% CI −4.4% to −2.4%
P ≤ 0.001
Intervention vs Standard care
difference in differences −3.4 % (95% CI −4.4% to −2.4%); P ≤ 0.001
As reported in the abstract
Further findings
| Outcome | difference in differences (mmol/L) (95% CI) | P value | |
|---|---|---|---|
| LDL-C · 36 months | −1.2 (−1.4 to −1.0) | P ≤ 0.001 | |
| −2−101Difference, mmol/L (linear scale) |
| Outcome | Estimate | P value |
|---|---|---|
| SBP, sustained vs unsustained CAC image recall at 24 months (within intervention) · 36 months | DID −4.3 mmHg (95% CI −7.7 to −0.9) | P = 0.01 |
| Waist circumference, sustained vs unsustained CAC image recall at 24 months (within intervention) · 36 months | DID −2.0 cm (95% CI −3.9 to −0.1) | P = 0.03 |
Original publication
Influence of repeated plaque visualization on cardiovascular risk reduction after 3 years: a randomized controlled trial. Eur J Prev Cardiol. Published 19 January 2024. doi:10.1093/eurjpc/zwae026
Summarised from the published abstract; every number is checked against it