Arrhythmias & electrophysiologySecondary analysis
Influence of sex on efficacy of exercise training for patients with symptomatic atrial fibrillation: insights from the ACTIVE-AF randomized controlled trial
- Secondary analysis of the ACTIVE-AF randomised trial
- sex subgroup analysis
Authors' conclusion
An exercise-based intervention reduced arrhythmia recurrence for both men and women with symptomatic AF. Symptom severity was reduced with exercise in women at 12 months. No difference was observed in symptom severity for men.
Study context
- Population
- Patients with symptomatic paroxysmal or persistent atrial fibrillation (AF)69 men · 51 women
- Participants
- 120 patients
- Comparison
- Exercise training vs standard medical care, by sex
- Primary endpoint
- Co-primary: AF recurrence (off anti-arrhythmic medications, without catheter ablation) and AF symptom severity scores
- Follow-up
- 12 months
Primary result
As reported in the abstract
AF recurrence, by sex
Exercise vs Standard medical careHazard ratio (95% CI)P value
men
0.52(0.29–0.91)
P = 0.022women
0.47(0.23–0.95)
P = 0.035- AF recurrence in men
- 50 (73%)
- AF recurrence in women
- 34 (67%)
Original publication
Influence of sex on efficacy of exercise training for patients with symptomatic atrial fibrillation: insights from the ACTIVE-AF randomized controlled trial. Eur J Prev Cardiol. Published 24 July 2023. doi:10.1093/eurjpc/zwad242
Summarised from the published abstract; every number is checked against it