Heart failure & cardiomyopathiesMeta-analysis
Influenza Vaccination and Cardiovascular Events in Patients with Ischaemic Heart Disease and Heart Failure: A Meta-Analysis
- Systematic review and meta-analysis of randomised trials
- random effects and fixed effects models
Authors' conclusion
In this meta-analysis of available RCTs in patients at high cardiovascular risk, influenza vaccination was associated with a reduced incidence of cardiovascular events, cardiovascular death and all-cause death as compared to placebo or no treatment.
Study context
- Population
- Patients with ischaemic heart disease or HF
- Participants
- 9,340 patients · 6 randomized controlled trials (RCTs)
- Comparison
- Influenza vaccination vs placebo or no treatment
- Outcome
- Composite of:
- CV death
- ACS
- Stent thrombosis or coronary revascularization
- Stroke
- HF hospitalization
Pooled result
As reported in the abstract
Hazard ratio
0.74
95% CI 0.63–0.88
P < 0.001
Influenza vaccination vs Placebo or no treatment
HR 0.74 (95% CI 0.63–0.88); P < 0.001
Further pooled results
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CV death · random effects; I2 = 58% | 0.63 (0.42–0.95) | P = 0.028 | |
| All-cause death · random effects; I2 = 52% | 0.72 (0.54–0.95) | P = 0.0227 | |
| 0.512Hazard ratio (log scale) |
Sensitivity analysis excluding non peer-reviewed data
- Results similar when non peer-reviewed data excluded
Original publication
Influenza Vaccination and Cardiovascular Events in Patients with Ischaemic Heart Disease and Heart Failure: A Meta-Analysis. Eur J Heart Fail. Published 5 July 2023. doi:10.1002/ejhf.2945
Summarised from the published abstract; every number is checked against it