Pulmonary vascular disease & thromboembolism
Inhaled Nitric Oxide Testing in Predicting Prognosis in Pulmonary Hypertension Due to Left-Sided Heart Diseases
Main finding · All-cause death or hospitalization for HFResult — go to the resultHazard ratio 4.35 95% CI 1.27–14.83Authors' conclusion
Patients with Group 2 PH were tolerant of the inhaled NO test. NO-induced PAWP is a novel prognostic indicator.
Study context
- Population
- Patients with PH due to left-sided heart disease (Group 2 PH; mean pulmonary arterial pressure ≥25 mmHg, pulmonary arterial wedge pressure (PAWP) >15 mmHg), 2011–2015median follow-up 365 days
- Participants
- 69 patients
- Exposure
- Increased PAWP vs no increased PAWP after inhaled nitric oxide (NO) vasoreactivity test
- Increased PAWPn = 34
- No increase in PAWPn = 35reference
- Outcome
- All-cause death or hospitalization for heart failure (HF)
- Follow-up
- 1 year
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hazard ratio
4.35
95% CI 1.27–14.83
P = 0.019
Increased PAWPvs No increase in PAWP
HR 4.35 (95% CI 1.27–14.83); P = 0.019
Observational data: associations, not effects.
Further findings
- Acute response of PAWP to NO differed between HFpEF and HFrEF
Safety
- No adverse events observed after NO inhalation
Original publication
Inhaled Nitric Oxide Testing in Predicting Prognosis in Pulmonary Hypertension Due to Left-Sided Heart Diseases. ESC Heart Fail. Published 29 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →