Arrhythmias & electrophysiologyCross-sectional study
Insights into adherence to medication and lifestyle recommendations in an international cohort of patients with catecholaminergic polymorphic ventricular tachycardia
- Cross-sectional study
- online multilingual survey
- international
Authors' conclusion
The significant rate of non-adherence associated with concerns regarding CPVT-related medication, emphasizes the potential for improving therapy adherence by targeted patient education.
Study context
- Population
- Patients with catecholaminergic polymorphic VT (catecholaminergic polymorphic ventricular tachycardia (CPVT)), international cohort200 prescribed medication
- Participants
- 218 patients
- Outcome
- Self-reported non-adherence to medication (Medication Adherence Rating Scale (MARS)) and lifestyle recommendations
Main finding
As reported in the abstract
Non-adherence
- Non-adherent to medication
- 30 (15%)
- Exercising more than recommended
- 19 (13.4%)
- Female sex associated with non-adherence
- OR 3.7 (1.3-12.0), P = 0.019 (95% CI)
- Flecainide monotherapy vs combination therapy associated with non-adherence
- OR 6.8 (1.6-31.0), P = 0.010 (95% CI)
- Higher concerns about CPVT medication associated with non-adherence
- OR 1.2 (1.1-1.3), P < 0.001 (95% CI)
Observational data: associations, not effects.
Further findings
Syncope, aborted cardiac arrest or appropriate ICD shock after diagnosis
- Patients with event
- 34 (17%)
Original publication
Insights into adherence to medication and lifestyle recommendations in an international cohort of patients with catecholaminergic polymorphic ventricular tachycardia. Europace. Published 13 February 2024. doi:10.1093/europace/euae044
Summarised from the published abstract; every number is checked against it