Cardiometabolic & kidneyCross-sectional study
Insulin Resistance and N-Terminal Pro-B-Type Natriuretic Peptide Among Healthy Adults
- Cross-sectional study
Authors' conclusion
In a national sample of US adults, insulin resistance was inversely associated with NT-proBNP, even after rigorously accounting for multiple measures of fat mass and lean mass.
Study context
- Population
- US adults aged ≥20 years without DM or CVD, NHANES 1999–2004
- Participants
- 4,038 adults
- Exposure
- Insulin resistance measures vs NT-proBNP, by sex
- Outcome
- Adjusted changes in NT-proBNP by insulin resistance levels
Main finding
As reported in the abstract
% change in NT-proBNP per SD increase in HOMA-IR (adjusted incl. CV risk factors, body mass index (BMI), waist circumference, DEXA fat and lean mass)
Percent change, % (95% CI)
Women
−16.84(−21.23% to −12.21%)
Men
−19.04(−24.14 to −13.59)
Per SD increase in HOMA-IR, as printed
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| Other insulin resistance indices and HOMA-β vs NT-proBNP, by sex — Women · QUICKI | 17.27 (95% CI 10.92–23.99) |
| Other insulin resistance indices and HOMA-β vs NT-proBNP, by sex — Men · QUICKI | 22.17 (95% CI 15.27–29.48) |
| Other insulin resistance indices and HOMA-β vs NT-proBNP, by sex — Women · TyG index | −11.47 (95% CI −16.12 to −6.57) |
| Other insulin resistance indices and HOMA-β vs NT-proBNP, by sex — Men · TyG index | −15.81 (95% CI −20.40 to −10.95) |
| Other insulin resistance indices and HOMA-β vs NT-proBNP, by sex — Women · IGR | −15.15 (95% CI −19.35 to −10.74) |
| Other insulin resistance indices and HOMA-β vs NT-proBNP, by sex — Men · IGR | −16.61 (95% CI −21.63 to −11.26) |
| Other insulin resistance indices and HOMA-β vs NT-proBNP, by sex — Women · fasting insulin | −16.32 (95% CI −20.63 to −11.78) |
| Other insulin resistance indices and HOMA-β vs NT-proBNP, by sex — Men · fasting insulin | −18.22 (95% CI −23.30 to −12.79) |
| Other insulin resistance indices and HOMA-β vs NT-proBNP, by sex — Women · HOMA-β | −10.71 (95% CI −14.71 to −6.52) |
| Other insulin resistance indices and HOMA-β vs NT-proBNP, by sex — Men · HOMA-β | −11.72 (95% CI −16.35 to −6.85) |
Other insulin resistance indices and HOMA-β vs NT-proBNP, by sex
- Similar associations observed for other indices of insulin resistance
Original publication
Insulin Resistance and N-Terminal Pro-B-Type Natriuretic Peptide Among Healthy Adults. JAMA Cardiol. Published 1 October 2023. doi:10.1001/jamacardio.2023.2758
Summarised from the published abstract; every number is checked against it