HypertensionCohort study
Insulin resistance drives cognitive impairment in hypertensive pre-diabetic frail elders: the CENTENNIAL study
- Prospective cohort study
- consecutive patients
- single-centre
Authors' conclusion
Taken together, our data highlight for the first time the association between insulin resistance and global cognitive function in frail elders with hypertension and pre-diabetes.
Study context
- Population
- Frail, hypertensive, pre-diabetic elders (age >65 years, Montreal Cognitive Assessment (MoCA) Score <26), Avellino local health authority (ASL AV), Italy, March 2021–March 2022141 completed
- Participants
- 178 participants
- Outcome
- Association between insulin resistance (HOMA-IR) and cognitive impairment (MoCA Score)
Main finding
As reported in the abstract
Correlation between MoCA Score and HOMA-IR
Strong inverse correlation between MoCA Score and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (r)
−0.807
Observational data: associations, not effects.
Original publication
Insulin resistance drives cognitive impairment in hypertensive pre-diabetic frail elders: the CENTENNIAL study. Eur J Prev Cardiol. Published 17 May 2023. doi:10.1093/eurjpc/zwad173
Summarised from the published abstract; every number is checked against it