Acute cardiac care & resuscitationCohort study
Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes
- hospital-based longitudinal, observational cohort
Authors' conclusion
Although lower API and CPO are known prognostic metrics in patients with cardiogenic shock, these findings support their broader utility across the spectrum of cardiovascular disease.
Study context
- Population
- Patients who underwent right heart catheterizationpatients included (age 64 ± 11 years, 36.5% women, 35.3% prior heart failure)
- Participants
- 4,278 patients
- Exposure
- lowest vs highest aortic pulsatility index (API) and cardiac power output (CPO) quartiles
Main finding
As reported in the abstract
Events: deaths, MACE, HFH · mean of 7 ± 3.2 years
deaths
1,552
Major adverse cardiovascular events (MACE)
1,429
Heart failure hospitalization (HFH)
991
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality, MACE, HFH by API quartile — lowest API quartile vs highest API quartile · death | 2.06 (1.71–2.47) | P < 0.001 | |
| All-cause mortality, MACE, HFH by API quartile — lowest API quartile vs highest API quartile · MACE | 1.94 (1.65–2.30) | P < 0.001 | |
| All-cause mortality, MACE, HFH by API quartile — lowest API quartile vs highest API quartile · HFH | 2.82 (2.31–3.45) | P < 0.001 | |
| All-cause mortality, MACE, HFH by CPO quartile — lowest CPO quartile vs highest CPO quartile · death | 1.25 (1.08–1.46) | P < 0.005 | |
| All-cause mortality, MACE, HFH by CPO quartile — lowest CPO quartile vs highest CPO quartile · MACE | 1.51 (1.29–1.78) | P < 0.005 | |
| All-cause mortality, MACE, HFH by CPO quartile — lowest CPO quartile vs highest CPO quartile · HFH | 1.90 (1.57–2.30) | P < 0.005 | |
| 0.20.5125Hazard ratio (log scale) |
- All-cause mortality, MACE, HFH by API quartile: all P < 0.001
- All-cause mortality, MACE, HFH by CPO quartile: all P < 0.005
Original publication
Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes. JACC Adv. Published 15 May 2026. doi:10.1016/j.jacadv.2026.102786
Summarised from the published abstract; every number is checked against it