Arrhythmias & electrophysiologyCohort study
Integrated hemodynamic sensing, electrical sensing, and ventricular pacing from a novel substernal lead: An acute human study
- prospective first-in-human feasibility study
Authors' conclusion
Acute placement of this multifunctional substernal lead was feasible and enabled integrated hemodynamic and electrical sensing with acute ventricular capture. These findings provide preliminary human support for further development of physiology-guided extravascular implantable cardioverter defibrillator systems; chronic performance and clinical validation of the hemodynamic sensing algorithm require further study.
Study context
- Population
- Patients undergoing cardiac surgery or epicardial ventricular tachycardia (VT) ablationpatients enrolled
- Participants
- 5 patients
Main finding
As reported in the abstract
- Lead placement and removal were successful in all patients
Observational data: associations, not effects.
Further findings
Interpretable hemodynamic signals
- Interpretable hemodynamic signals obtained in all patients
- 5
- Stable beat-to-beat temporal correspondence with the electrocardiogram and distinct rhythm-associated patterns across sinus rhythm, atrial fibrillation, VT, and ventricular fibrillation
VT episodes with interpretable hemodynamic-index recordings
- All VT episodes had interpretable hemodynamic-index recordings
- 147
Hemodynamic index during arrhythmia
- Decreased abruptly during VT and recovered after arrhythmia termination
- Corresponding changes during transitions among VT, ventricular fibrillation, and sinus rhythm
Ventricular capture
- Ventricular capture achieved in all patients
- 5
- Capture voltage
- 11-17 V
- Mean capture voltage
- 13.8 V
- Pulse width
- 0.5 ms
Original publication
Summarised from the published abstract; every number is checked against it