Heart failure & cardiomyopathiesCohort study
Integrated Role of Cardiac Magnetic Resonance and Genetics in Predicting Left Ventricular Reverse Remodelling in Dilated and Non-Dilated Cardiomyopathy
- Multicentre observational cohort study
Authors' conclusion
In a large genetically and CMR characterized DCM/NDLVC cohort, arrhythmogenic genotypes and LGE ring-like pattern were inversely related to LVRR, particularly in patients with LVEF <35%.
Study context
- Population
- DCM/non-dilated left ventricular cardiomyopathy (NDLVC) patients with baseline left ventricular ejection fraction (LVEF) <50%, genetic testing, baseline cardiac magnetic resonance (CMR) and 12-month echo follow-upof 1757 with genetic data
- Participants
- 616 patients
- Exposure
- DCM vs NDLVC; predictors of left ventricular reverse remodelling (LVRR)
- DCMn = 462
- NDLVCn = 154
- Outcome
- LVRR (LVEF increase ≥10% or LVEF ≥50% if baseline LVEF <45%)
- Follow-up
- 12 months
Main finding
As reported in the abstract
LVRR
P = 0.004
- LVRR overall
- 314 (51%)
Observational data: associations, not effects.
Further findings
LVRR and SCD/MVA, LVEF <35% (subgroup)
- Only late gadolinium enhancement (LGE) ring-like pattern and arrhythmogenic genes remained independently related to lower LVRR rate and increased SCD/MVA risk
Original publication
Integrated Role of Cardiac Magnetic Resonance and Genetics in Predicting Left Ventricular Reverse Remodelling in Dilated and Non-Dilated Cardiomyopathy. Eur J Heart Fail. Published 29 April 2025. doi:10.1002/ejhf.3671
Summarised from the published abstract; every number is checked against it