Heart failure & cardiomyopathiesResearch article
Integrating Genotyping and Left Atrial Strain Analysis Enhances Risk Stratification in Hypertrophic Cardiomyopathy
- exploratory study
Authors' conclusion
LARS was associated with progression to LVSD in HCM, potentially reflecting the preclinical stage of LVSD, whereas LVGLS was not. In this exploratory study, integrating left atrial strain analysis with genotyping may have potential value in risk stratification, with implication for early detection of vulnerable individuals.
Study context
- Population
- Genotyped patients with hypertrophic cardiomyopathy (HCM)23.8% sarcomere positive, followed up for 5.0 (IQR: 2.4–8.7) years
- Participants
- 101 patients
- Comparison
- Association of myocardial strain parameters (left ventricular global longitudinal strain (LVGLS), left atrial reservoir strain (LARS)) and genotype with progression to left ventricular systolic dysfunction (LVSD)
- Outcome
- Progression to LVSD (ejection fraction <50%)
Main finding
As reported in the abstract
Estimate (95% CI)P value
Sarcomere positive
sHR 5.07(1.25–20.6)
P = 0.023lower LARS
sHR 1.10 per 1% decrease(1.02–1.18)
P = 0.015Sarcomere-positive patients with reduced LARS
sHR 8.31(2.25–30.7)
P = 0.001Per 1% decrease, as printed
Secondary outcomes
Secondary endpoint: composite of progression to LVSD, heart-failure hospitalization, and all-cause death
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| Sarcomere-positive patients with reduced LARS | 4.76 (1.59–14.2) | P = 0.005 | |
| 0.050.21520Hazard ratio (log scale) |
Association between genotype and strain parameters
- No significant association was observed between genotype and strain parameters
Original publication
Integrating Genotyping and Left Atrial Strain Analysis Enhances Risk Stratification in Hypertrophic Cardiomyopathy. JACC Adv. Published 22 June 2026. doi:10.1016/j.jacadv.2026.102863
Summarised from the published abstract; every number is checked against it