Prevention & lipidsCohort study
Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease
- Cohort study
- external replication
Authors' conclusion
This study demonstrates that absolute CVD risk, determined by a clinical risk score, and relative genetic risk, determined by a PRS, provide independent information.
Study context
- Population
- UK Biobank participants; replication in combined Framingham/ARIC populationsreplication n = 10,757
- Participants
- 432,981 participants
- Exposure
- SCORE2 × polygenic risk score (PRS)-factor vs SCORE2 alone
- Outcome
- Incident CVD (coronary artery disease (CAD) or stroke); risk reclassification by the multiplicative model
Main finding
As reported in the abstract
Reclassification by SCORE2 × PRS-factor (UK Biobank)
Intermediate risk (n = 145 337) moved to high risk
9.55%
Increase in individuals at high risk
56.6%
Incident cardiovascular disease (CVD), reclassified intermediate to high risk
8.08%
Incident CVD, remained at intermediate risk
4.08%
Observational data: associations, not effects.
Further findings
Reclassification in Framingham/ARIC (replication)
- Shifted from moderate to high risk
- 8.29%
Original publication
Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease. Eur Heart J. Published 29 March 2024. doi:10.1093/eurheartj/ehae048
Summarised from the published abstract; every number is checked against it