Coronary disease & ACSCohort study
Intensive early and sustained lowering of non–high-density lipoprotein cholesterol after myocardial infarction and prognosis: the SWEDEHEART registry
- Registry-based cohort study
Authors' conclusion
The lowest achieved levels both at 2 months and at 1 year of non-HDL-C were associated with better outcome. The lowest risk was observed when target was achieved within 2 months of MI and sustained thereafter.
Study context
- Population
- Patients with myocardial infarction (MI) in the SWEDEHEART registry
- Participants
- 56,262 patients
- Exposure
- Lowest vs highest quartile of achieved non-HDL-C after MI
- Outcome
- MACE:
- Death
- MI
- Ischaemic stroke
- Follow-up
- Median 5.4 years
Main finding
MACE by achieved non-HDL-C at 1 year
Hazard ratio
0.76
95% CI 0.71–0.81
Lowest quartile vs Highest quartile
HR 0.76 (95% CI 0.71–0.81)
As reported in the abstract
- MACE events
- 9549
Observational data: associations, not effects.
Further findings
MACE by non-HDL-C level at 2 months, incl. early events up to 1 year
- Short-term results consistent with the 1-year analysis
- HR 0.80, 95% CI 0.68-0.92
Outcomes by timing of non-HDL-C target achievement (<2.2 mmol/L)
- Early and sustained target achievement (lowest risk)
- HR 0.80, 95% CI 0.74-0.86
- Target achieved early or late
- HR 0.86, 95% CI 0.79-0.93
Death and non-fatal MI
- Similar results observed for all outcomes
Original publication
Intensive early and sustained lowering of non–high-density lipoprotein cholesterol after myocardial infarction and prognosis: the SWEDEHEART registry. Eur Heart J. Published 1 September 2024. doi:10.1093/eurheartj/ehae576
Summarised from the published abstract; every number is checked against it