Heart failure & cardiomyopathiesMeta-analysis
Intentional Weight Loss in Overweight and Obese Patients with Heart Failure: A Systematic Review
- Systematic review
Authors' conclusion
All forms of weight loss intervention studied in this review were likely to result in significant weight loss, improved symptoms and QOL.
Study context
- Population
- Overweight and obese patients with heart failure (HF) (HF patients with obesity (HFpwO))
- Participants
- 22 studies
- Comparison
- Intentional weight loss interventions in HF patients with obesity
- Lifestyle interventionn = 9
- Pharmacotherapyn = 3
- Bariatric surgeryn = 10
Pooled result
As reported in the abstract
Weight loss, symptoms, QOL, LVEF and adverse events by intervention type
- Semaglutide (1 randomized controlled trial (RCT), HF with preserved ejection fraction (HFpEF)): weight loss with improvement in quality of life (QOL)
- Lifestyle intervention: weight loss, minimal adverse events and improved symptoms in HF with reduced ejection fraction (HFrEF) and HFpEF
- Bariatric surgery (6 observational studies, HFrEF): weight loss and improved left ventricular ejection fraction (LVEF) safely in most patients; some developed worsening HF perioperatively
- all studies moderate to high risk of bias except one RCT
Safety
Worsening HF after bariatric surgery · perioperatively
- Bariatric surgery safe in most HFrEF patients but some developed worsening HF perioperatively
- 6 observational studies
Original publication
Intentional Weight Loss in Overweight and Obese Patients with Heart Failure: A Systematic Review. Eur J Heart Fail. Published 16 May 2024. doi:10.1002/ejhf.3270
Summarised from the published abstract; every number is checked against it