Cardiometabolic & kidneyCohort study
Interaction between type 2 diabetes polygenic risk and physical activity on cardiovascular outcomes
- Prospective cohort study
Authors' conclusion
The beneficial effect of physical activity on cardiovascular outcomes disappeared among those with high genetic risk for type 2 diabetes.
Study context
- Population
- Participants with diabetes, UK Biobank
- Participants
- 25,701 participants
- Exposure
- Interaction between T2D polygenic risk score and physical activity
- Outcome
- Three-point and four-point MACE
Main finding
As reported in the abstract
Interaction between PRS_T2D and physical activity on three-point and four-point MACE
Interaction PRS_T2D × physical activity, three-point major adverse cardiovascular events (MACE)
P trend for interaction = 0.0081
Interaction PRS_T2D × physical activity, four-point MACE
P trend for interaction = 0.0037
Observational data: associations, not effects.
Further findings
Intense physical activity (>80 metabolic equivalents (METs) h/week; self-reported by 12.7%), restricted cubic spline
- Intense physical activity increased risk of CV outcomes in PRS_T2D fourth quartile
Intense physical activity, by insulin use (subgroup)
- Negative impact of intense physical activity observed only in non-insulin users
Original publication
Interaction between type 2 diabetes polygenic risk and physical activity on cardiovascular outcomes. Eur J Prev Cardiol. Published 22 February 2024. doi:10.1093/eurjpc/zwae075
Summarised from the published abstract; every number is checked against it