Arrhythmias & electrophysiology
Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation
Main finding · AF incidence per 1000 person-years, high genetic riskResult — go to the resultRelative excess risk due to interaction 0.86 95% CI 0.68–1.03Authors' conclusion
The rates of AF increased gradually with worse lifestyle within each category of genetic risk. We found a positive interaction on an additive scale between genetic risk and lifestyle
Study context
- Population
- Danish Diet, Cancer and Health cohort; genetic risk score of 142 variants: low (quintile 1), intermediate (quintiles 2–4), high (quintile 5)3,094 atrial fibrillation (AF) cases
- Exposure
- Lifestyle by genetic risk
- Outcome
- Incident AF; interaction between lifestyle and genetic risk
- Follow-up
- Median 12.9 years
Methodological detailsrandomly drawn subcohort
- Randomly drawn subcohort
Main finding
As reported in the abstract
AF incidence per 1000 person-years, high genetic risk
Relative excess risk due to interaction
0.86
95% CI 0.68–1.03
P < 0.001
By group
Observational data: associations, not effects.
Original publication
Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation. Heart. Published 28 November 2023. doi:10.
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