Arrhythmias & electrophysiology

Interatrial Block Association With Adverse Cardiovascular Outcomes in Patients Without a History of Atrial Fibrillation

JACC Clin ElectrophysiolPublished Retrospective cohort study

Main finding · StrokeResult — go to the resultRMTLRC 1.43 95% CI 1.35–1.51

Authors' conclusion

IAB is independently associated with stroke in patients with no history of AF/AFL even after adjustment for incident AF/AFL and CHA2DS2-VASc score.

Study context

Population
Patients without prior atrial fibrillation (AF)/atrial flutter (AFL)no prior AF/AFL
Participants
458,994 patients
Exposure
Interatrial block (IAB) vs no IAB
  • IABn = 86,317
  • No IABn = 355,032reference
Outcome
Stroke
Methodological details5-center
  • 5-center

Main finding

As reported in the abstract

RMTLRC

1.43

95% CI 1.35–1.51

Observational data: associations, not effects.

Further findings

OutcomeRMTLRC (95% CI)
MortalityTau = 1,9241.14 (1.07–1.21)
HFTau = 1,9211.94 (1.83–2.04)
Systemic thromboembolismTau = 1,8971.62 (1.53–1.71)
Incident AF/AFLTau = 1,8881.16 (1.10–1.22)

IAB prevalence

Overall
19.6%
Black
26.1%
White
20.9%
Hispanic
18.5%
Native Americans
9.2%

Stroke in pre-existing AF/AFL (subgroup)

IAB not associated with stroke

Original publication

Interatrial Block Association With Adverse Cardiovascular Outcomes in Patients Without a History of Atrial Fibrillation. JACC Clin Electrophysiol. Published 21 June 2023. doi:10.1016/j.jacep.2023.04.006

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