Heart failure & cardiomyopathiesMeta-analysis
Interchangeability of the KCCQ-12 and Kansas City Cardiomyopathy Questionnaire (KCCQ-23) Across >18,000 Participants Enrolled in 4 Large-Scale Trials of Heart Failure
- Participant-level pooled analysis of 4 randomised clinical trials
- TOPCAT, PARAGON-HF, DELIVER, FINEARTS-HF
Authors' conclusion
In patients with HFmrEF/HFpEF, the KCCQ-12 closely parallels the KCCQ-23, demonstrating comparable prognostic performance and treatment responsiveness.
Study context
- Population
- Adults with HFmrEF/HFpEF
- Participants
- 18,216 adults · 4 RCTs
- Comparison
- KCCQ-12 vs KCCQ-23
- Outcome
- Interchangeability (concordance) of KCCQ-12 OSS and KCCQ-23 OSS
Pooled result
As reported in the abstract
Concordance of baseline OSS (0 worst to 100 best) · baseline
KCCQ-12
64.1
SD 21.7
KCCQ-23
65.5
SD 21.4
- Spearman ρ, baseline KCCQ-12 overall summary scores (OSS) vs KCCQ-23 OSS
- 0.987
- Consistent across major subgroups and follow-up visits (all Spearman ρ)
- > 0.980
Further pooled results
| Outcome | KCCQ-12 | KCCQ-23 |
|---|---|---|
| Prognostic discrimination for CV death and HF hospitalisation | ||
| C index | 0.586 | 0.583 |
Prognostic discrimination for CV death and heart failure (HF) hospitalisation
- Comparable
Treatment effects of HF drugs on KCCQ-OSS · each time point
- Similar across the 2 instruments in each trial; all differences between KCCQ-23 and KCCQ-12 on a 0-100 scale
- <1 point
Original publication
Interchangeability of the KCCQ-12 and KCCQ-23 Across >18,000 Participants Enrolled in 4 Large-Scale Trials of Heart Failure. J Am Coll Cardiol. Published 16 March 2026. doi:10.1016/j.jacc.2026.03.026
Summarised from the published abstract; every number is checked against it