Heart failure & cardiomyopathies
Internal Carotid Artery Blood Flow and Pulsatility Index in Cognitively Impaired People with Chronic Heart Failure
Authors' conclusion
ICA-BF and ICA-PI, measured in broadly available extracranial sonography, independently related to measures of functional and structural brain changes in people with chronic HF, respectively.
Study context
- Population
- Chronic heart failure (HF) patients without AF or carotid artery stenosis (aged 63 ± 10 years; 19% women)
- Participants
- 107 patients
- Primary endpoint
- Association of internal carotid artery (ICA) blood flow (BF) and pulsatility index (PI) with chronic HF parameters, brain morphologic measures and cognitive impairment
Methodological detailscross-sectional
- Cross-sectional
Primary result
As reported in the abstract
- ICA-BF, median (quartiles), mL/min
- 630 (570, 700)
- ICA-PI, median (quartiles)
- 1.05 (0.96. 1.23)
- Higher ICA-PI associated with increased white matter hyperintensity volume beyond ageing
- r = 0.25; P = 0.011
- ICA-BF and white matter hyperintensity volume (not associated)
- r = 0.08; P = 0.409
- ICA-BF correlated with age-adjusted executive function T-scores (ICA-PI did not)
- r = 0.38; P < 0.001
- ICA-BF correlated with working memory
- r = 0.32; P < 0.001
- ICA-BF correlated with visual/verbal fluency
- r = 0.32; P < 0.001
- Multivariate linear model of executive function: only ICA-BF remained significant (not HF or MRI parameters)
- T = 3.79; P < 0.001
Original publication
Internal Carotid Artery Blood Flow and Pulsatility Index in Cognitively Impaired People with Chronic Heart Failure. ESC Heart Fail. Published 4 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →