Arrhythmias & electrophysiology
An international multicenter cohort study on implantable cardioverter-defibrillators for the treatment of symptomatic children with catecholaminergic polymorphic ventricular tachycardia
Authors' conclusion
SCD events occurred only in patients without an ICD and mostly in those not on optimal medical therapy.
Study context
- Population
- Symptomatic children (<19 years) with catecholaminergic polymorphic ventricular tachycardia (CPVT) (RYR2 variants, phenotype-positive) without history of sudden cardiac arrest at phenotype diagnosis
- Participants
- 235 children
- Exposure
- ICD vs no ICD
- ICDn = 73
- No ICDn = 162reference
- Outcome
- SCD
- Follow-up
- Median 8.0 years (IQR 4.3-13.4 years)
Main finding
As reported in the abstract
median follow-up 8.0 years
ICD
0
events
- Sudden cardiac death (SCD) occurred overall in 7 patients
- 3.0%
- Of SCD cases, noncompliant with medications
- 4 (57.1%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Composite SCD, sudden cardiac arrest or appropriate ICD shocks (without arrhythmic syncope) | 5.85 (3.40–10.09) | P < 0.0001 | |
| Composite SCD, sudden cardiac arrest or appropriate ICD shocks (with arrhythmic syncope) | 2.55 (1.50–4.34) | P = 0.0005 | |
| 0.050.21520Hazard ratio (log scale) |
Safety
- ICD shocks and device-related complications
- 31 (42.5%) · Appropriate shocks · Inappropriate shocks 18 (24.7%) · Device-related complications 21 (28.8%)
Original publication
An international multicenter cohort study on implantable cardioverter-defibrillators for the treatment of symptomatic children with catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. Published 7 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →