Coronary disease & ACSTrial design
International study of coronary microvascular angina (iCorMicA): A registry-based diagnostic study and nested randomized trial
- international, multicenter, prospective, registry-based study and nested, randomized, controlled, triple-blind, and endpoint trial
- Participants, community care providers, and outcomes assessors are masked
Study context
- Population
- Patients with angina undergoing invasive management (coronary angiography); participants without obstructive coronary artery disease eligible for randomizationenrolled into the registry · randomized 1,047 · not randomized (registry-only) 386
- Participants
- 1,483 patients
- Planned comparison
- coronary function test-guided management vs results not disclosed
- Primary endpoint
- Within-individual change in Seattle Angina Questionnaire summary score (randomized trial)
- Follow-up
- 12-months from baseline
No results yet. This paper sets out the design of a trial; its results are to come.
Further findings
Study conduct
- First patient screened
- December 18, 2020
- Last patient enrolled
- June 30, 2026
- Sites
- Forty
- United Kingdom
- n = 35
- Republic of Ireland
- n = 2
- Holland
- n = 2
- Poland
- n = 1
Original publication
International study of coronary microvascular angina (iCorMicA): A registry-based diagnostic study and nested randomized trial. Am Heart J. Published 6 July 2026. doi:10.1016/j.ahj.2026.107527
Summarised from the published abstract; every number is checked against it