Heart failure & cardiomyopathiesMeta-analysis
Interventions for Optimization of Guideline-Directed Medical Therapy
- Systematic review of randomised trials
PubMed, Embase, Cochrane, CINAHL, Web of Science, January 2010 to November 2023 · Bias assessed with Cochrane Risk of Bias tool and Oxford Centre for Evidence-Based Medicine
Authors' conclusion
Initiatives that used interdisciplinary teams, largely comprised of nurses and pharmacists, most consistently led to improvements in GDMT.
Study context
- Population
- Patients with heart failure with reduced ejection fraction (HFrEF)
- Participants
- 19,840 patients · 28 RCTs
- Comparison
- System-level quality improvement interventions vs usual care
- Outcome
- GDMT use
Pooled result
As reported in the abstract
Interdisciplinary titration clinics vs usual care: greater proportion on target doses of β-blockers
10% to 60%
Interdisciplinary titration clinics vs usual care: greater proportion on target doses of renin-angiotensin-aldosterone system inhibitors
2% to 53%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Summarised from the published abstract; every number is checked against it