Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural–molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery
Authors' conclusion
The OCT-NIRF imaging with a clinical dose of ICG was feasible to accurately assess plaque inflammation and DES-related inflammation in a beating coronary artery.
Study context
- Population
- Atheromatous Yucatan minipigs and drug-eluting stent (DES)-implanted Yorkshire pigs12 minipigs · 7 DES pigs
- Comparison
- ICG vs saline before intracoronary OCT-NIRF imaging
- Outcome
- Estimation of coronary inflammation by intracoronary dual-modal OCT-NIRF imaging with ICG
Methodological detailsanimal study (swine), ex vivo and in vitro validation, human autopsy specimens, Rapid coronary imaging (20 mm/s pullback) with a fully integrated OCT-NIRF catheter, safely performed
- Animal study (swine)
- Ex vivo and in vitro validation
- Human autopsy specimens
- Rapid coronary imaging (20 mm/s pullback) with a fully integrated OCT-NIRF catheter, safely performed
Main finding
As reported in the abstract
Stronger near-infrared fluorescence (NIRF) activity in optical coherence tomography (OCT)-proven high-risk plaque vs normal or saline-injected controls; validated on ex vivo fluorescence reflectance imaging
P = 0.0016
In vivo plaque target-to-background ratio (pTBR) much higher in inflamed lipid-rich plaque vs fibrous plaque
P < 0.0001
In vivo and ex vivo peak pTBRs correlated significantly
P < 0.0022
NIRF signals along stent struts 2 weeks after DES deployment significantly higher than baseline
P = 0.0156
Original publication
Summarised from the published abstract; every number is checked against it