Prevention & lipidsCohort study
Intracranial Atherosclerotic Disease and Incident Dementia: The ARIC Study (Atherosclerosis Risk in Communities)
- Prospective cohort study
- community-based
- 4 US communities
Authors' conclusion
ICAD was associated with an increased risk of incident dementia, independent of CSVD, APOE4 genotype, and cardiovascular risk factors.
Study context
- Population
- Black and White ARIC participants without dementia with brain MRI (vessel wall MRI and MR angiography) 2011–2013, mean age 77.4 years1,590 followed
- Participants
- 1,980 participants
- Exposure
- Intracranial atherosclerotic disease (ICAD) vs no ICAD
- Outcome
- Incident dementia
- Follow-up
- Median 5.6 years
Main finding
As reported in the abstract
Each group vs no ICADHazard ratio (95% CI)
Any ICAD
1.57(1.17–2.11)
ICAD stenosis ≤50%
1.41(1.02–1.95)
ICAD stenosis >50%
1.94(1.32–2.84)
- Participants who developed dementia
- 286
- ICAD prevalence
- 34.6%
Observational data: associations, not effects.
Further findings
Incident dementia, low white matter hyperintensity burden (subgroup)
- ICAD associated with dementia even with low white matter hyperintensity burden
Original publication
Intracranial Atherosclerotic Disease and Incident Dementia: The ARIC Study (Atherosclerosis Risk in Communities). Circulation. Published 1 August 2024. doi:10.1161/circulationaha.123.067003
Summarised from the published abstract; every number is checked against it