Heart failure & cardiomyopathiesCohort study
Intrarenal Venous Flow Pattern Changes Do Relate With Renal Function Alterations in Acute Heart Failure
- Prospective cohort study
- multicentre
Authors' conclusion
Discontinuous IRVF identifies patients with higher odds of WRF during admission and postdischarge periods. Nonetheless, adequate diuretic response and decongestion could modify this association. Patients showing both WRF and discontinuous IRVF at 30 days had increased rates of adverse events.
Study context
- Population
- Patients with acute HF
- Participants
- 188 patients
- Exposure
- Discontinuous vs continuous intrarenal venous flow (IRVF) patterns
- Outcome
- Worsening renal function (WRF)
- Follow-up
- 72 hours and 30 days
Main finding
As reported in the abstract
WRF
Discontinuous IRVF vs Continuous IRVFOdds ratio (95% CI)P value
at 72 hours
3.90(1.24–12.20)
P = 0.020at 30 days
5.76(1.67–19.86)
P = 0.006Observational data: associations, not effects.
Further findings
| Outcome | difference (mg/dL) (95% CI) | P value | |
|---|---|---|---|
| Change in serum creatinine — Discontinuous IRVF vs Continuous IRVF · Δ-72 hours | 0.14 (0.06–0.22) | P = 0.001 | |
| Change in serum creatinine — Discontinuous IRVF vs Continuous IRVF · Δ-discharge | 0.13 (0.03–0.23) | P = 0.007 | |
| −0.100.10.20.3Difference, mg/dL (linear scale) |
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Adverse events, WRF plus discontinuous IRVF at 30 days | 5.96 (2.63–13.52) | P < 0.001 | |
| 0.050.21520Hazard ratio (log scale) |
Change in serum creatinine
- Diuretic response and decongestion significantly influenced the magnitude of these changes
Original publication
Intrarenal Venous Flow Pattern Changes Do Relate With Renal Function Alterations in Acute Heart Failure. JACC Heart Fail. Published 6 September 2023. doi:10.1016/j.jchf.2023.07.015
Summarised from the published abstract; every number is checked against it