Arrhythmias & electrophysiologyResearch article

Intraseptal Mapping of Premature Ventricular Complexes Using Multipolar Catheters

JACC Clin ElectrophysiolPublished

  • mapping and ablation experience

Authors' conclusion

Ablation of LVOT PVCs guided by intraseptal mapping using multipolar catheters is feasible and highly effective. Electrocardiogram predictors of SOO identify patients in whom intraseptal mapping may be useful. Reversal of late potentials with PVCs may represent abnormal substrate in idiopathic PVCs in ostensibly structurally normal hearts.

Study context

Population
Patients with suspected left ventricular outflow tract (LVOT) premature ventricular complexes (PVCs) in whom intraseptal mapping was attempted using multipolar cathetersmultipolar intraseptal mapping successfully performed in 60 (70%)
Participants
86 patients

Main finding

As reported in the abstract

Successful multipolar intraseptal mapping

Successfully performed

60 (70%)

Female

30%

With prior ablation

53%

Further findings

Site of origin

PVCs were most commonly mapped to an intramyocardial source and least commonly to the epicardium

ECG predictors of site of origin (SOO)

LBBB PVCs: V2 S-wave pattern break (PB) ratio ruled in an intramyocardial or epicardial source
>2.7
LBBB PVCs: V2 S-wave PB ratio ruled out an endocardial source
<1.2
RBBB morphology PVCs: V2 R-wave PB ratio ruled out an endocardial source
<1.0

Acute ablation success

Acute ablation success
98%

Freedom from recurrence · median follow-up of 12.4 months

Freedom from recurrence
93%

Intraseptal late potentials with reversal during PVC

Observed
25 (42%) patients
Associated with long-term success

Original publication

Intraseptal Mapping of Premature Ventricular Complexes Using Multipolar Catheters. JACC Clin Electrophysiol. Published 16 May 2026. doi:10.1016/j.jacep.2026.03.017

Summarised from the published abstract; every number is checked against it