Arrhythmias & electrophysiology
Intravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes
Authors' conclusion
These findings suggest that intravascular sympathetic stimulation via the VV can be used to safely provoke PVCs during catheter ablation.
Study context
- Population
- Adults undergoing catheter ablation of premature ventricular complexes (PVCs) with rare or absent PVCs despite standard provocation, Hospital of the University of Pennsylvania, 2022–20247 with prior unsuccessful ablation
- Participants
- 15 adults
- Exposure
- PVC frequency before, during and after VV stimulation
- Outcome
- PVC frequency
- Follow-up
- Before, during and after stimulation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
| Group | Value | Median [IQR] |
|---|---|---|
| Before VV stimulation | mean 1.3 (SD 1.4) PVCs | 1.0 [0.0-2.5] PVCs |
| During VV stimulation | mean 8.2 (SD 5.7) PVCs per minute | 6.0 [4.5-13.0] PVCs per minute |
| After VV stimulation | mean 5.1 (SD 6.6) PVCs per minute | 3.0 [0.5-6.5] PVCs per minute |
Value
Before VV stimulationmean 1.3 (SD 1.4) PVCs
During VV stimulationmean 8.2 (SD 5.7) PVCs per minute
After VV stimulationmean 5.1 (SD 6.6) PVCs per minute
Median [IQR]
Before VV stimulation1.0 [0.0-2.5] PVCs
During VV stimulation6.0 [4.5-13.0] PVCs per minute
After VV stimulation3.0 [0.5-6.5] PVCs per minute
Observational data: associations, not effects.
Further findings
Postablation PVC burden
- Mean (SD) PVC burden
- 1.3% (2.3%)
- Median [IQR] PVC burden
- 0.0% [0.0%-2.5%]
- Patients with <1% PVC burden
- 9 of 15
- Ablation guided by activation mapping in 7 patients, pace mapping alone in the rest
Safety
- Adverse events related to VV stimulation
- 0
Original publication
Intravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes. JAMA Cardiol. Published 1 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →