Coronary disease & ACSRandomised controlled trial
Intravascular Ultrasound vs Angiography-Guided Drug-Coated Balloon Angioplasty
- Randomised controlled trial
Authors' conclusion
This study demonstrated that IVUS-guided DCB angioplasty is associated with a lower LLL in patients with a de novo coronary lesion compared with angiography guidance.
Study context
- Population
- Patients with high bleeding risk and a de novo coronary lesion (reference vessel diameter 2.0–4.0 mm, lesion length ≤15 mm)
- Participants
- 260 patients
- Comparison
- Intravascular ultrasound (IVUS)-guided vs angiography-guided drug-coated balloon (DCB) angioplasty
- Primary endpoint
- In-segment late lumen loss (LLL)
- Follow-up
- 7 months after procedure
Primary result
In-segment LLL · 7 months
Mean difference
0.14 mm
95% CI 0.02–0.26
P = 0.025
By group
Angiography guidance
0.03
mean · SD 0.52 · mm
IVUS guidance
−0.10
mean · SD 0.34 · mm
Angiography guidance vs IVUS guidance
mean difference 0.14 mm (95% CI 0.02–0.26); P = 0.025
As reported in the abstract
Secondary outcomes
| Outcome | Values | P value |
|---|---|---|
| Target vessel failure · 6 months | Angiography-guided 3.1% · IVUS-guided 0.8% | P = 0.370 |
| Minimal lumen diameter · 7 months | P < 0.001 | |
| Diameter stenosis · 7 months | P = 0.001 |
Safety
events
| Outcome | Angiography-guided | IVUS-guided | P value |
|---|---|---|---|
| Bailout stent implantation | 2 | 7 | P = 0.172 |
Original publication
Intravascular Ultrasound vs Angiography-Guided Drug-Coated Balloon Angioplasty. JACC Cardiovasc Interv. Published 5 June 2024. doi:10.1016/j.jcin.2024.04.014
Summarised from the published abstract; every number is checked against it