Coronary disease & ACSDiagnostic or prognostic study

Invasive Right Anomalous Coronary Arteries Assessment

JACC AdvPublished

  • Prospective single-center diagnostic accuracy study
  • consecutive patients
  • prospectively enrolled

Authors' conclusion

In adults with newly diagnosed R-AAOCA and interarterial and intramural course, one-quarter were hemodynamically relevant. FFRAdenosine could reliably rule-in, while IVUS-MLA could effectively rule-out relevant R-AAOCA, potentially reducing the need for FFRDobutamine testing.

Study context

Population
Patients with R-AAOCA and interarterial/intramural coursepatients included, 17 (23%) with hemodynamically relevant R-AAOCA
Participants
73 patients
Comparison
Diagnostic accuracy of FFRAdenosine and IVUS-MLA against the reference standard of FFRDobutamine for identifying hemodynamically relevant R-AAOCA

Performance

As reported in the abstract

Hemodynamically relevant R-AAOCA (FFRDobutamine ≤0.80)

Patients with hemodynamically relevant R-AAOCA

Seventeen patients (23%)

Further findings

Diagnostic performance for FFRDobutamine ≤0.80

threshold FFRAdenosine ≤0.80 · IVUS-MLA ≤5.5 mm²

specificity

positive predictive value

sensitivity

negative predictive value

area under the curve FFRAdenosine 0.81 · IVUS-MLA 0.88

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Invasive Right Anomalous Coronary Arteries Assessment. JACC Adv. Published 24 January 2026. doi:10.1016/j.jacadv.2025.102526

Summarised from the published abstract; every number is checked against it