Prevention & lipidsCohort study
Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation
- Prospective cohort study with mechanistic experiments
Authors' conclusion
The present epidemiologic data suggest that increasing low circulating ApoC-II levels may reduce cardiovascular risk.
Study context
- Population
- LURIC participants590 CV deaths
- Participants
- 3,141 participants
- Exposure
- ApoC-II quintiles
- Outcome
- Cardiovascular mortality
- Follow-up
- Median 9.9 (IQR 8.7-10.7) years
Main finding
As reported in the abstract
CV mortality by ApoC-II quintile
- Trend toward inverse J-shape: highest risk in lowest quintile, lowest in middle quintile
- Q2–Q5 vs Q1: all P < 0.05
- multivariate adjustment including ApoC-III
Observational data: associations, not effects.
Further findings
ApoC-II concentration
- Mean ApoC-II concentration, mg/dL (SD)
- 4.5 (2.4)
Effect of exogenous ApoC-II on GPIHBP1-LPL activity (fluorometric substrate assays)
- Bell-shaped relationship
GPIHBP1-LPL activity with neutralizing anti-ApoC-II antibody (very low-density lipoprotein (VLDL) substrate assays)
- Almost completely blocked
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation. Eur Heart J. Published 8 May 2023. doi:10.1093/eurheartj/ehad261
Summarised from the published abstract; every number is checked against it