Arrhythmias & electrophysiologyRandomised controlled trial
Iodinated Adhesive Drapes for Repeat Cardiac Implantable Device Implantation
- Randomised controlled trial
- single-blinded
- single-centre
- 1:1 randomisation
Authors' conclusion
In this randomized clinical trial, the use of iodine-impregnated drapes during repeat CIED implantation resulted in reduction in swab culture positivity and 1-year CIED infection rates.
Study context
- Population
- Patients undergoing repeat procedures on the same cardiac implantable electronic device (CIED) pocket189 + 195 analysed
- Participants
- 418 patients
- Comparison
- Iodine-impregnated adhesive drape vs no drape
- Drapen = 210
- No-drapen = 208reference
- Primary endpoint
- End-of-procedure pocket-swab culture positivity
Primary result
Pocket-swab culture positivity
Relative risk reduction
0.50
95% CI 0.24–0.75
P = 0.005
Events by treatment group
Drape vs No-drape
relative risk reduction 0.50 (95% CI 0.24–0.75); P = 0.005
As reported in the abstract
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| CIED infection by swab result (positive vs negative swabs) · 2 of 59 (3.4%) vs 2 of 325 (0.6%) | 5.67 (0.78–41.04) | P = 0.08 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | Drape | No-drape | Estimate | P value |
|---|---|---|---|---|
| Adjudicated CIED infections | 0 events | 1.9% | P = 0.02 |
Original publication
Iodinated Adhesive Drapes for Repeat Cardiac Implantable Device Implantation. JAMA Cardiol. Published 1 October 2025. doi:10.1001/jamacardio.2025.2835
Summarised from the published abstract; every number is checked against it