Heart failure & cardiomyopathiesCross-sectional study
Iron deficiency and bone metabolism in heart failure
- Cross-sectional study
Authors' conclusion
In HF, a TSAT <20% is associated with disturbed bone metabolism
Study context
- Population
- Patients with chronic heart failure (HF) from SICA-HF
- Participants
- 198 patients
- Exposure
- Iron deficiency vs no iron deficiency
- Outcome
- Bone mineral density (BMD)
Main finding
BMD
Adjusted odds ratio
3.45
P = 0.01
By group
As reported in the abstract
- Graded dose-response across transferrin saturation (TSAT) quartiles
- P for trend = 0.0009
- Prevalence of TSAT <20%
- 29.8%
Observational data: associations, not effects.
Further findings
Plasma dihydroxy vitamin D · lower with ID
P = 0.03
| Outcome | Estimate | P value |
|---|---|---|
| Serum FGF-23 (pg/mL) · higher with ID | adjusted β 0.20 | P = 0.0009 |
| BMD above sex-specific medians (multivariable) | aOR 3.45 | P = 0.01 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Iron deficiency and bone metabolism in heart failure. Eur J Heart Fail. Published 19 August 2026. doi:10.1093/ejhf/xuag259
Summarised from the published abstract; every number is checked against it