Coronary disease & ACSSecondary analysis
Ischemia on Dobutamine Stress Echocardiography Predicts Efficacy of Percutaneous Coronary Intervention (PCI)
- Secondary analysis of the ORBITA-2 randomised trial
- placebo-controlled
- Dobutamine stress echocardiography (DSE)-stratified
- Bayesian proportional odds modeling
Authors' conclusion
In patients with single- and multivessel stable CAD on little or no antianginal medication, the placebo-controlled efficacy of PCI was predicted by the degree of ischemia detected on DSE.
Study context
- Population
- Angina with single-vessel or multivessel stable coronary artery disease (CAD) and ischemia, on little or no antianginal medicationwith prerandomization DSE data
- Participants
- 262 participants
- Comparison
- PCI vs placebo, by ischemia on DSE
- PCIn = 133
- Placebon = 129reference
- Primary endpoint
- Interaction between stress echocardiography score on DSE and placebo-controlled improvement in angina symptom score after PCI
Primary result
As reported in the abstract
Angina symptom score, per higher stress echocardiography score
Odds ratio
1.23
95% CrI 1.13–1.35
By group
PCI
1.42
median
Placebo
1.00
median
PCI vs Placebo
OR 1.23 (95% CrI 1.13–1.35)
Further findings
Daily angina episodes by symptom characteristics
- Relationship between stress echocardiography score and reduction in daily angina episodes consistent, irrespective of symptom characteristics
Original publication
Ischemia on Dobutamine Stress Echocardiography Predicts Efficacy of PCI. J Am Coll Cardiol. Published 13 May 2025. doi:10.1016/j.jacc.2025.02.034
Summarised from the published abstract; every number is checked against it