Coronary disease & ACSCohort study
Isoflavone Intake and the Risk of Coronary Heart Disease in US Men and Women
- Prospective cohort study
- pooled analysis of NHS, NHSII and Health Professionals Follow-Up Study cohorts
- multivariable-adjusted
Authors' conclusion
Higher intake of isoflavones and tofu was associated with a moderately lower risk of developing CHD, and in women the favorable association of tofu were more pronounced in young women or postmenopausal women without hormone use.
Study context
- Population
- US women (NHS, NHSII) and men (Health Professionals Follow-Up Study) free of CVD and cancer at baselinepooled cohorts
- Exposure
- Highest vs lowest quintile of isoflavone intake
- Outcome
- Incident CHD (nonfatal MI and CHD deaths)
Main finding
CHD
Pooled hazard ratio
0.87
95% CI 0.81–0.94
P = 0.008
Highest quintile vs Lowest quintile
pooled HR 0.87 (95% CI 0.81–0.94); P = 0.008
As reported in the abstract
- Incident coronary heart disease (CHD) cases
- 8359
- Person-years of follow-up
- 4 826 122
Observational data: associations, not effects.
Further findings
| Outcome | pooled HR (95% CI) | P value | |
|---|---|---|---|
| CHD by tofu and soy milk intake (≥1 serving/week vs <1 serving/month) — Tofu ≥1 serving/week vs <1 serving/month · tofu | 0.82 (0.70–0.95) | P = 0.005 | |
| CHD by tofu and soy milk intake (≥1 serving/week vs <1 serving/month) — Soy milk ≥1 serving/week vs <1 serving/month · soy milk | 0.87 (0.69–1.10) | P = 0.41 | |
| 0.512Pooled hazard ratio (log scale) |
Tofu and CHD in women, by menopause and hormone use (subgroup)
- Stronger inverse association in younger premenopausal women and postmenopausal women without hormone use
- P for interaction = 0.002
Original publication
Isoflavone Intake and the Risk of Coronary Heart Disease in US Men and Women. Circulation. Published 23 March 2020. doi:10.1161/circulationaha.119.041306
Summarised from the published abstract; every number is checked against it