Arrhythmias & electrophysiology
Ivabradine and Atrial Fibrillation Incidence: A Nested Matching Study
Main findingResult — go to the resultAdjusted hazard ratio 7.293 95% CI 4.985–10.668Authors' conclusion
The risk of AF over 180-day period was higher among HF patients who received IVB vs those who did not receive IVB.
Study context
- Population
- Adult heart failure (HF) patients free from atrial fibrillation (AF), health plan claims databasematched analytic cohort
- Participants
- 107 vs 321
- Exposure
- Ivabradine vs no ivabradine
- Ivabradine (IVB)n = 107
- Controls (CTRs)n = 321reference
- Outcome
- New AF diagnosis
- Follow-up
- 180-day follow-up
Methodological detailsmatched (incidence-density sampling), claims database
- Matched (incidence-density sampling)
- Claims database
Main finding
As reported in the abstract
Adjusted hazard ratio
7.293
95% CI 4.985–10.668
IVBvs CTRs
adjusted HR 7.293 (95% CI 4.985–10.668)
Observational data: associations, not effects.
Original publication
Ivabradine and Atrial Fibrillation Incidence: A Nested Matching Study. JACC Adv. Published 28 October 2025. doi:10.
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