Coronary disease & ACSMeta-analysis
Joint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States
- Time-stratified case-crossover study
- 2-stage model
- multivariate random-effects meta-analysis of climate region-specific estimates
Authors' conclusion
Joint exposure to ozone pollution and high temperature increased the probability of AMI among younger adults, even when one of the exposures was moderate.
Study context
- Population
- Adults aged 18 to 64 years with incident acute myocardial infarction (AMI), nationwide private insurance, contiguous US, 2016–2020
- Participants
- 270,123 adults
- Comparison
- Joint ozone-temperature exposures vs reference
- Outcome
- Incident AMI
- Follow-up
- Lag 0 day
Pooled result
As reported in the abstract
Increase (95% CI)
Ozone 60 ppb, temperature 95th percentile vs Ozone 35 ppb, temperature 1st percentile
33%(16%–51%)
Ozone 50 ppb, temperature median vs Ozone 35 ppb, temperature 1st percentile
15%(4%–28%)
Further pooled results
Incident AMI, by sex (subgroup)
- Heterogeneity by sex: women had increased odds when both ozone and temperature were high; men when either was high
Original publication
Joint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States. Circulation. Published 3 June 2025. doi:10.1161/circulationaha.124.073614
Summarised from the published abstract; every number is checked against it