Heart failure & cardiomyopathiesSecondary analysis
Kidney failure risk equation and risk of kidney and cardiovascular outcomes in patients with heart failure with reduced ejection fraction: insights from PARADIGM-HF
- Secondary analysis of the PARADIGM-HF randomised trial
Authors' conclusion
These data suggest that the KFRE is associated with risk of cardiovascular events in patients with HFrEF.
Study context
- Population
- Patients with HF and reduced EF (HFrEF) and chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR)<60 ml/min/1.73m2) with all Kidney Failure Risk Equation (KFRE) variables available
- Participants
- 794 patients
- Comparison
- KFRE score and CV and kidney outcomes
Primary result
As reported in the abstract
Association of KFRE 5-year score with outcomes
Hazard ratio (95% CI)P value
KFRE 5-year scorecomposite of ESKD or 50% decline in eGFR; few events, wide CI
1.45(0.93–2.25)
P = 0.10Continuous KFRE 5-year scoreCV death or HF hospitalization
1.22(1.09–1.36)
P < 0.001Continuous KFRE 5-year scoreall-cause mortality
1.24(1.10–1.39)
P < 0.001- Median 5-year KFRE score
- 0.63% [0.28%-1.67%]
Further findings
Baseline characteristics by KFRE score
- Higher KFRE score: higher SBP and NT-proBNP, more often DM or AF history, or diuretics at baseline
Original publication
Kidney failure risk equation and risk of kidney and cardiovascular outcomes in patients with heart failure with reduced ejection fraction: insights from PARADIGM-HF. Eur J Heart Fail. Published 8 April 2026. doi:10.1093/ejhf/xuag079
Summarised from the published abstract; every number is checked against it