Kidney Injury After Minimal Radiographic Contrast Administration in Patients With Acute Coronary Syndromes
Primary resultResult — go to the resultRelative risk 0.66 95% CI 0.47–0.93Authors' conclusion
CM volume reduction obtained using the CM diversion system is effective for prevention of AKI in patients with ACS undergoing invasive procedures.
Study context
- Population
- Patients with acute coronary syndromes (ACS) undergoing invasive coronary procedures, 4 Italian centres, 2020–20227 without postprocedural serum creatinine (sCr)
- Participants
- 550 patients
- Comparison
- Contrast volume reduction with DyeVert contrast media (CM) diversion system vs conventional injection
- Contrast volume reduction (CVR)n = 276
- Controln = 274reference
- Primary endpoint
- Acute kidney injury (AKI) (serum creatinine increase ≥0.3 mg/dL)
- Follow-up
- Within 48 hours after CM exposure
Methodological detailssingle-blind, investigator-driven, 4 Italian centres, 1:1 randomisation
- Single-blind
- Investigator-driven
- 4 Italian centres
- 1:1 randomisation
Primary result
As reported in the abstract
Relative risk
0.66
95% CI 0.47–0.93
P = 0.018
Events by treatment group
CVRvs Control
RR 0.66 (95% CI 0.47–0.93); P = 0.018
Further findings
CM volume
- CM volume: P < 0.001
Original publication
Kidney Injury After Minimal Radiographic Contrast Administration in Patients With Acute Coronary Syndromes. J Am Coll Cardiol. Published 19 March 2024. doi:10.
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