Coronary disease & ACSRandomised controlled trial
Kidney Injury After Minimal Radiographic Contrast Administration in Patients With Acute Coronary Syndromes
- Randomised controlled trial
- single-blind
- investigator-driven
- 4 Italian centres
- 1:1 randomisation
Authors' conclusion
CM volume reduction obtained using the CM diversion system is effective for prevention of AKI in patients with ACS undergoing invasive procedures.
Study context
- Population
- Patients with acute coronary syndromes (ACS) undergoing invasive coronary procedures, 4 Italian centres, 2020–20227 without postprocedural serum creatinine (sCr)
- Participants
- 550 patients
- Comparison
- Contrast volume reduction (CVR) vs Control
- CVRn = 276
- Controln = 274reference
- Primary endpoint
- Acute kidney injury (AKI) (serum creatinine increase ≥0.3 mg/dL)
- Follow-up
- Within 48 hours after CM exposure
Primary result
As reported in the abstract
Relative risk
0.66
95% CI 0.47–0.93
P = 0.018
Events by treatment group
CVR vs Control
RR 0.66 (95% CI 0.47–0.93); P = 0.018
Further findings
CM volume
- Contrast media (CM) volume: P < 0.001
Original publication
Kidney Injury After Minimal Radiographic Contrast Administration in Patients With Acute Coronary Syndromes. J Am Coll Cardiol. Published 19 March 2024. doi:10.1016/j.jacc.2024.01.016
Summarised from the published abstract; every number is checked against it