Heart failure & cardiomyopathies
Kidney Outcomes Among Medicare Beneficiaries After Hospitalization for Heart Failure
Authors' conclusion
In this study, older adults with HF had substantial risk of kidney complications, with an estimated 6% progressing to dialysis in the year after HF hospitalization.
Study context
- Population
- Adults aged ≥65 years hospitalized for heart failure (HF), Get With The Guidelines-Heart Failure registry, US, 2014–2018; prior or in-hospital dialysis excluded
- Participants
- 85,298 adults
- Exposure
- Discharge estimated glomerular filtration rate (eGFR) categories
- Outcome
- Inpatient dialysis initiation
- Follow-up
- 1 year after HF hospitalization
Methodological detailsregistry linked to Medicare claims, 372 sites
- Registry linked to Medicare claims
- 372 sites
Main finding
As reported in the abstract
Dialysis by 1 year
Adjusted hazard ratio (95% CI)
eGFR 45 to <60 vs eGFR ≥60dialysis readmission
2.16(1.86–2.51)
eGFR <30 vs eGFR ≥60dialysis readmission
28.46(25.25–32.08)
Per 10 mL/min per 1.73 m² lower eGFRreadmission for dialysis
2.23(2.14–2.32)
- Progressed to dialysis by 1 year (overall)
- 6%
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| Dialysis or end-stage kidney disease; readmission for AKI · 1 yearPer 10 mL/min per 1.73 m² lower eGFR · dialysis or end-stage kidney disease | 2.34 (2.24–2.44) | |
| Dialysis or end-stage kidney disease; readmission for AKI · 1 yearPer 10 mL/min per 1.73 m² lower eGFR · AKI | 1.25 (1.23–1.27) | |
| 0.512Adjusted hazard ratio (log scale) |
- Dialysis or end-stage kidney disease; readmission for acute kidney injury (AKI) — Progressed to dialysis or end-stage kidney disease (overall)
- 7%
- Dialysis or end-stage kidney disease; readmission for AKI — Readmitted for AKI (overall)
- 7%
All-cause mortality, all-cause readmission, HF readmission
- Similar findings with lower discharge eGFR
Effect modification by baseline LVEF
- Baseline LVEF did not modify the association between lower eGFR and kidney outcomes
Original publication
Kidney Outcomes Among Medicare Beneficiaries After Hospitalization for Heart Failure. JAMA Cardiol. Published 1 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →