Pulmonary vascular disease & thromboembolism
Lactobacillus Restructures the Micro/Mycobiome to Combat Inflammation-Mediated Right Ventricular Dysfunction in Pulmonary Arterial Hypertension
Authors' conclusion
Lactobacillus supplementation restructures the gut micro/mycobiome, restores intestinal health, dampens systemic inflammation, and reduces GP130 ligands and associated RV cardiomyocyte microtubule remodeling. These data identify a novel microbiome-inflammation-microtubule axis that has therapeutic relevance for RV dysfunction.
Study context
- Population
- Rats with monocrotaline-induced PAH; patients with PAHpatients with PAH in whom the relationship between Lactobacillus abundance and right ventricular (RV) function was assessed
- Participants
- 65 rats
- Exposure
- Lactobacillus administration in monocrotaline rats; patients with PAH with vs without detectable fecal Lactobacillus
- Outcome
- Intestinal micro- and mycobiome
Main finding
As reported in the abstract
- Lactobacillus administration restructured both the intestinal micro- and mycobiome
Observational data: associations, not effects.
Further findings
Intestinal health
- Increased jejunal villus length and glycocalyx thickness and diminished intestinal permeability biomarkers
Serum proteomics
- Lactobacillus modulated systemic inflammation and decreased circulating GP130 ligands
RV cardiomyocyte microtubule remodeling and associated phenotypes
- Lactobacillus-mediated suppression of GP130 signaling blunted pathological microtubule remodeling in RV cardiomyocytes
- RV cardiomyocyte and nuclear hypertrophy, transverse tubule integrity, and connexin-43 localization were all corrected with Lactobacillus
RV function and PAH severity
- Improved RV function despite no significant alteration in PAH severity
RV function in patients with PAH by detectable fecal Lactobacillus
- Patients with PAH and detectable fecal Lactobacillus had superior RV function despite similar mean pulmonary arterial pressure and pulmonary vascular resistance as compared with those without detectable Lactobacillus
Original publication
Lactobacillus Restructures the Micro/Mycobiome to Combat Inflammation-Mediated Right Ventricular Dysfunction in Pulmonary Arterial Hypertension. Circ Heart Fail. Published 16 May 2025. doi:10.
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