HypertensionRandomised controlled trial
Lay community health worker-led care with mobile decision support for uncontrolled hypertension: a cluster-randomized trial
- Cluster-randomised controlled trial
- 1:1
- nested within the ComBaCaL cohort study
- 103 rural villages
Authors' conclusion
Among people with uncontrolled hypertension, lay CHW-led, CDSS-supported care was safe and more effective than referral to facility-based professional care.
Study context
- Population
- Nonpregnant adults with blood pressure (BP) ≥140/90 mm Hg after community-based screening, rural Lesotho543 in ITT analysis
- Participants
- 547 adults
- Comparison
- Intervention vs Control
- Interventionn = 273
- Controln = 274reference
- Primary endpoint
- BP <140/90 mm Hg
- Follow-up
- 12 months
Primary result
BP control
Adjusted odds ratio
1.52
95% CI 1.01–2.29
P = 0.046
Events by treatment group
Intervention vs Control
adjusted OR 1.52 (95% CI 1.01–2.29); P = 0.046
As reported in the abstract
Safety
Safety outcomes
- No relevant differences in safety outcomes
Original publication
Lay community health worker-led care with mobile decision support for uncontrolled hypertension: a cluster-randomized trial. Nat Med. Published 12 February 2026. doi:10.1038/s41591-026-04208-w
Summarised from the published abstract; every number is checked against it