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Arrhythmias & electrophysiologyCohort study

Left atrial ablation using the dual-energy, lattice-tip catheter in the SAFE-Ablation Registry: How to avoid procedure-related stroke?

Heart RhythmPublished

  • single-center retrospective registry
  • consecutive patients
  • 2 sequential timeframes
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Authors' conclusion

During left-sided RFA with the lattice-tip catheter, use of the default settings is associated with procedure-related stroke. Ablation is safest when employing PFA-only or RFA using attenuated energy settings.

Study context

Population
Consecutive patients undergoing left atrial ablation using the dual-energy, lattice-tip catheter (de novo and redo-ablation)patients undergoing catheter ablation · Period-1 294 · Period-2 213
Participants
507 patients
Exposure
Pulsed field ablation (PFA)+RFALA using default radiofrequency (RF) settings vs PFA-only or PFA+RFALA-Attenuated
  • PFA+RFALAn = 164
  • PFA-onlyn = 130
  • PFA-onlyn = 136
  • PFA+RFALA-Attenuatedn = 77

Main finding

As reported in the abstract

Procedure-related stroke, Period-1

P = 0.073

Patients with procedure-related stroke during Period-1, all when using PFA+RFALA
4 patients (1.4%)

Observational data: associations, not effects.

Further findings

Procedure-related stroke, combined cohorts

P = 0.004

  • Procedure-related stroke, combined cohorts: stroke significantly more likely with PFA+RFALA using default RF settings

Procedure-related stroke, Period-2

213 procedures using PFA-only or PFA+RFALA-Attenuated, all without stroke

Redo-ablation

Redo-ablation
54.4%

Original publication

Left atrial ablation using the dual-energy, lattice-tip catheter in the SAFE-Ablation Registry: How to avoid procedure-related stroke? Heart Rhythm. Published 11 April 2026. doi:10.1016/j.hrthm.2026.04.001
Read the original article ↗PubMedCite RIS · BibTeX

Summarised from the published abstract; every number is checked against it