Arrhythmias & electrophysiologyMeta-analysis
Left atrial appendage occlusion in patients with end-stage renal disease: an individual patient-level meta-analysis
- Systematic review and individual patient-level meta-analysis
- aggregate and individual patient data meta-analyses
Authors' conclusion
LAAO represents a feasible option for thromboembolic prevention in patients with ESRD, although these patients have an increased risk of complications and bleeding.
Study context
- Population
- Patients with AF undergoing left atrial appendage occlusion (LAAO), with or without end-stage renal disease
- Participants
- 24,127 patients · 17 studies
- Comparison
- LAAO in patients with end-stage renal disease (ESRD) vs without ESRD
- ESRDn = 1,047
Pooled result
As reported in the abstract
Thromboembolic events during follow-up
ESRD vs No ESRDHazard ratio (95% CI)
stroke/TIA, individual patient data (7 studies, n = 4745, 268 ESRD)
1.22(0.66–2.26)
- aggregate data
- IRR 1.44; P = 0.16
Safety
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Major bleeding · individual patient data | 1.65 (1.01–2.69) | ||
| 0.20.5125Hazard ratio (log scale) |
| Outcome | ESRD | No ESRD | Estimate | P value |
|---|---|---|---|---|
| Procedural complications | pooled rate 4% (95% CI 1–9%) | Not reported in the abstract | RR 2.23 | P = 0.02 |
| Major bleeding · aggregate data | IRR 1.84 | P < 0.01 |
Original publication
Left atrial appendage occlusion in patients with end-stage renal disease: an individual patient-level meta-analysis. Europace. Published 29 August 2025. doi:10.1093/europace/euaf198
Summarised from the published abstract; every number is checked against it