Heart failure & cardiomyopathies
Left Atrial Enlargement is Associated with Pulmonary Vascular Disease in Heart Failure with Preserved Ejection Fraction
Authors' conclusion
Increasing LA volume may be associated with more advanced pulmonary vascular disease in HFpEF, featuring higher PVR and pulmonary pressures. Reduced LA function, worse at increasing LA volumes, is associated with a disrupted PVR-compliance relationship, further augmenting impaired pulmonary haemodynamics.
Study context
- Population
- Patients with HFpEF (HF symptoms, LVEF ≥50%, haemodynamic features of HFpEF) undergoing exercise right heart catheterization and echocardiography
- Participants
- 85 patients
- Exposure
- Left atrial (LA) volume index tertiles
- Outcome
- Relationship between LA volume and pulmonary arterial haemodynamics
Methodological detailsRetrospective analysis
- Retrospective analysis
Main finding
As reported in the abstract
Pulmonary haemodynamics by LA volume
- LA volume associated with blunted increases in cardiac output with exercise
- padjusted <0.001
- LA volume associated with higher resting mean pulmonary artery pressure
- padjusted = 0.003
- Similar wedge pressure
- padjusted = 1
- Pulmonary vascular resistance (PVR) increased with increasing LA volume
- padjusted <0.001
- Larger LA volumes featured reduced LA strain
- padjusted <0.001
Observational data: associations, not effects.
Further findings
| Outcome | Reduced strain | Preserved strain | P value |
|---|---|---|---|
| PVR-compliance time, reduced (≤24%) vs preserved LA global reservoir strain (subgroup) | 0.34 (range 0.28–0.40) | 0.38 (range 0.33–0.43) | P = 0.03 |
- PVR-compliance time, reduced (≤24%) vs preserved LA global reservoir strain (subgroup): subgroup n = 60
Original publication
Left Atrial Enlargement is Associated with Pulmonary Vascular Disease in Heart Failure with Preserved Ejection Fraction. Eur J Heart Fail. Published 15 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →