Heart failure & cardiomyopathies
Left atrial late gadolinium enhancement and atrial fibrillation in hypertrophic cardiomyopathy
Main finding · Incident AF (sinus rhythm, no prior AF)Result — go to the resultHazard ratio 15.81 95% CI 2.48–100.73Authors' conclusion
LALGE is independently associated with AF and reflects advanced atrial remodeling in HCM.
Study context
- Population
- Patients with hypertrophic cardiomyopathy followed at a tertiary centre, 2009–202368 in sinus rhythm without prior atrial fibrillation (AF)
- Participants
- 78 patients
- Exposure
- Left atrial late gadolinium enhancement (LALGE) vs no LALGE
- LALGEn = 14
- Outcome
- Association between LALGE and AF (incident AF among sinus rhythm patients)
Methodological detailslongitudinal, tertiary centre
- Longitudinal
- Tertiary centre
Main finding
Incident AF (sinus rhythm, no prior AF)
Hazard ratio
15.81
95% CI 2.48–100.73
P = 0.003
By group
LALGE
9.1%/year
No LALGE
1.75%/year
LALGEvs No LALGE
HR 15.81 (95% CI 2.48–100.73); P = 0.003
As reported in the abstract
Observational data: associations, not effects.
Further findings
LALGE frequency, AF vs no AF
P = 0.014
Structural correlates
- LALGE correlated with larger LA diameter, mitral regurgitation and obstructive physiology
Original publication
Left atrial late gadolinium enhancement and atrial fibrillation in hypertrophic cardiomyopathy. Heart Rhythm. Published 8 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →