Heart failure & cardiomyopathies
Left atrial remodelling and function in various left ventricular hypertrophic phenotypes
Authors' conclusion
LA characteristics differ among LV hypertrophic phenotypes. LACI and iLAVmax are independently correlated with LA function, while LA sphericity correlates independently with LA reservoir strain.
Study context
- Population
- Patients with left ventricular (LV) hypertrophy of various phenotypes who underwent cardiac magnetic resonance, and individuals with normal CMRindividuals included
- Participants
- 375 patients
- Exposure
- Patients with LV hypertrophy who underwent CMR compared to a control group
- Hypertrophic cardiomyopathy (HCM)n = 148
- Cardiac amyloidosis (CA)n = 35
- Hypertensive (HTN) heart diseasen = 41
- Aortic stenosis (AS)n = 97
- Normaln = 54
- Outcome
- Indexed LA end-systolic volume, diastolic volume and LA sphericity
Main finding
As reported in the abstract
| Group | iLVmax | Diastolic volume | Left atrial (LA) sphericity |
|---|---|---|---|
| CA | 59.1 ± 16.9 mL/m² | 46.8 ± 16.4 mL/m² | 83.2 ± 2.1% |
CA
iLVmax59.1 ± 16.9 mL/m²
Diastolic volume46.8 ± 16.4 mL/m²
Left atrial (LA) sphericity83.2 ± 2.1%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| LACI | CA 58 ± 2% · HCM 42 ± 2% · HTN heart disease 39 ± 2% · AS 37 ± 2% · normal 22 ± 1% |
| LA reservoir and booster strain | CA LA reservoir 9.6% (0.6-18.6%) · booster strain 9.1 ± 5.4% |
Left atrioventricular coupling index (LACI)
- Higher LACI in CA; no differences across others
LA reservoir and booster strain
- Lowest in CA; no differences across other groups
Independent correlates of LA strain (multivariable linear regression)
- LACI with LA reservoir
- β = 0.15
- iLAVmax with LA reservoir
- β = −39.33
- LACI with LA conduit
- β = 0.08
- iLAVmax with LA conduit
- β = −17.08
- LACI with LA booster strain
- β = 0.1
- iLAVmax with LA booster strain
- β = −28.69
- LA sphericity with LA reservoir strain
- β = −0.51
- LV global longitudinal strain with LA reservoir
- β = −0.43
- LV global longitudinal strain with conduit
- β = −0.20
- LV global longitudinal strain with booster strain
- β = −0.24
Original publication
Left atrial remodelling and function in various left ventricular hypertrophic phenotypes. Eur Heart J Cardiovasc Imaging. Published 28 January 2025. doi:10.
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