Heart failure & cardiomyopathies
Left atrial reservoir strain as a novel predictor of new-onset atrial fibrillation in light-chain-type cardiac amyloidosis
Authors' conclusion
LASr was an independent predictor of NOAF in patients with ALCA.
Study context
- Population
- Patients with light-chain-type cardiac amyloidosis (ALCA), 2005–2019ALCA
- Participants
- 287 patients
- Exposure
- LASr ≤14.4% vs LASr >14.4%
- Outcome
- New-onset AF (NOAF)
- Follow-up
- Median 0.85 years
Methodological detailstwo tertiary centres
- Two tertiary centres
Main finding
As reported in the abstract
NOAF
Adjusted hazard ratio (95% CI)P value
LASr ≤14.4% vs LASr >14.4%independent predictor; held with all-cause death as competing risk
3.370(1.337–8.492)
P = 0.010Higher LASr (%)per % LASr, adjusted incl. LAVI and LV-GLS
0.936(0.879–0.997)
P = 0.039- Optimal LASr cut-off for new-onset atrial fibrillation (NOAF) (ROC)
- 14.4%
Observational data: associations, not effects.
Further findings
| Outcome | Net reclassification index | P value |
|---|---|---|
| Reclassification for NOAF: Model 3 (incl. LASr) vs Model 1 (LV-GLS) and Model 2 (LV-GLS plus LAVI)Model 3 vs Model 1 | 0.735 | P < 0.001 |
| Reclassification for NOAF: Model 3 (incl. LASr) vs Model 1 (LV-GLS) and Model 2 (LV-GLS plus LAVI)Model 3 vs Model 2 | 0.514 | P = 0.003 |
Original publication
Left atrial reservoir strain as a novel predictor of new-onset atrial fibrillation in light-chain-type cardiac amyloidosis. Eur Heart J Cardiovasc Imaging. Published 13 January 2023. doi:10.
Summarised from the published abstract; every number is checked against it