Heart failure & cardiomyopathies
Left Atrial to Coronary Sinus Shunting for Treatment of Symptomatic Heart Failure
Authors' conclusion
In this single-arm experience, the APTURE Transcatheter Shunt System in patients with symptomatic HF was observed to be safe and resulted in reduction in pulmonary capillary wedge pressure and clinically meaningful improvements in HF symptoms and quality of life indices.
Study context
- Population
- Patients with symptomatic heart failure (HF) with pulmonary capillary wedge pressure >15 mm Hg at rest or 25 mm Hg during exerciseattempted implantation
- Participants
- 87 patients
- Outcome
- Primary safety outcome
- Follow-up
- 30 days
Methodological detailssingle-arm, multicentre (18 centres), Enrolment May 2018 to September 2022
- Single-arm
- Multicentre (18 centres)
- Enrolment May 2018 to September 2022
Main finding
As reported in the abstract
Primary safety outcome occurred in 2 patients
2.3%
Further findings
Device success
- Device success achieved in 78 patients
- 90%
NYHA class I to II · 6 months
- Participants achieving NYHA class I to II
- 67%
KCCQ overall summary score improvement · 6 months
- 23-point improvement (95% CI: 17-29 points)
- P < 0.0001
20-W exercise PCWP · 6 months
- 7 mm Hg lower (95% CI: −11 to −4 mm Hg)
- P < 0.0001
- No change in right atrial pressure or other right heart function indices
Safety
Device occlusions or associated adverse events after implantation
- No device occlusions or associated adverse events
Original publication
Left Atrial to Coronary Sinus Shunting for Treatment of Symptomatic Heart Failure. JACC Cardiovasc Interv. Published 21 March 2023. doi:10.
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