Arrhythmias & electrophysiologyRandomised controlled trial
Left Atrial Volume as Predictor of Recurrence After Pulmonary Vein Isolation
- prospective randomized controlled trial
Authors' conclusion
In patients with PerAF undergoing PVI as the first ablation procedure, LAV is a strong predictor of AA recurrence and SMURDEN. LAV larger than 114 cc was associated with more than a 40% risk of recurrent arrhythmia.
Study context
- Population
- PerAF patients undergoing first-time ablationpatients analyzed
- Participants
- 361 patients
- Comparison
- Left atrial volume (LAV) as predictor of atrial arrhythmia (AA) recurrence and SMURDEN
- Primary endpoint
- Freedom from recurrent AA (procedural success)
- Follow-up
- Following a 90-day blanking period through 365 days postprocedure
Primary result
As reported in the abstract
Hazard ratio
0.53
95% CI 0.35–0.82
P = 0.04
LAV <114 cc
HR 0.53 (95% CI 0.35–0.82); P = 0.04
Further findings
Baseline LAV
- Median LAV
- 129 cc (IQR: 103.9-153.6)
- ROC optimal cut point for success
- LAV <114 cc
SMURDEN · beyond the 3-month blanking period
- Multivariate model of traditional risk factors, adjusted R2
- 0.12
- Only LAV and age remained significantly related
- P < 0.001
Original publication
Left Atrial Volume as Predictor of Recurrence After Pulmonary Vein Isolation. JACC Adv. doi:10.1016/j.jacadv.2026.103051
Summarised from the published abstract; every number is checked against it